People with Past COVID-19 Benefit from Immunization
Anthony L. Komaroff, MD, reviewing Stamatatos L et al. Science 2021 Mar 25 Reynolds CJ et al. Science 2021 Apr 30 Crotty S. Science 2021 Jun 25
Neutralizing antibody concentrations rose by about 100-fold after vaccination.
Initial Treatment of Multisystem Inflammatory Disease in Children
Deborah Lehman, MD, reviewing Son MBF et al. N Engl J Med 2021 Jul 1 McArdle AJ et al. N Engl J Med 2021 Jul 1
Two observational studies leave unanswered questions about the optimal initial treatment for MIS-C.
Heterologous COVID-19 Vaccination Enhances Immune Responses
Rajesh T. Gandhi, MD, reviewing Borobia AM et al. Lancet 2021 Jul 10
In recipients of one dose of AstraZeneca ChAdOx-1-S vaccine, the Pfizer-BioNTech BNT162b2 vaccine produced an augmented response.
Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination.Normark J, Vikström L, Gwon YD, Persson IL, Edin A, Björsell T, Dernstedt A, Christ W, Tevell S, Evander M, Klingström J, Ahlm C, Forsell M.N Engl J Med. 2021 Jul 14. doi: 10.1056/NEJMc2110716. Online ahead of print.PMID: 34260850
Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination.Barouch DH, Stephenson KE, Sadoff J, Yu J, Chang A, Gebre M, McMahan K, Liu J, Chandrashekar A, Patel S, Le Gars M, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H.N Engl J Med. 2021 Jul 14. doi: 10.1056/NEJMc2108829. Online ahead of print.PMID: 34260834
Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19.Dougan M, Nirula A, Azizad M, Mocherla B, Gottlieb RL, Chen P, Hebert C, Perry R, Boscia J, Heller B, Morris J, Crystal C, Igbinadolor A, Huhn G, Cardona J, Shawa I, Kumar P, Adams AC, Van Naarden J, Custer KL, Durante M, Oakley G, Schade AE, Holzer TR, Ebert PJ, Higgs RE, Kallewaard NL, Sabo J, Patel DR, Dabora MC, Klekotka P, Shen L, Skovronsky DM; BLAZE-1 Investigators.N Engl J Med. 2021 Jul 14. doi: 10.1056/NEJMoa2102685. Online ahead of print.PMID: 34260849
Study Suggests Lasting Immunity After COVID-19, With a Big Boost From Vaccination.Abbasi J.JAMA. 2021 Jul 14. doi: 10.1001/jama.2021.11717. Online ahead of print.PMID: 34259836
Covid-19: quanto a lungo dura l’immunità? Istituto di Ricerche Farmacologiche Mario Negri 14/7/2021
Potential New Blood Biomarker for Myocarditis Detection.Abbasi J.JAMA. 2021 Jul 13;326(2):124. doi: 10.1001/jama.2021.10618.PMID: 34255023