Attività in vitro delle Rifamicine contro Stafilococchi liberi o in biofilm isolati nelle infezioni periprotesiche

In Vitro Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection.

Albano M, Karau MJ, Greenwood-Quaintance KE, Osmon DR, Oravec CP, Berry DJ, Abdel MP, Patel R.

Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e00959-19. doi: 10.1128/AAC.00959-19.

Adeguata temporizzazione per la rimozione dell’impianto nelle infezioni periprotesiche acute (Olanda, Spagna et al.)

Timing of implant-removal in late acute periprosthetic joint infection: A multicenter observational study.

Wouthuyzen-Bakker M, Sebillotte M, Lomas J, Kendrick B, Palomares EB, Murillo O, Parvizi J, Shohat N, Reinoso JC, Sánchez RE, Fernandez-Sampedro M, Senneville E, Huotari K, Allende JMB, García AB, Lora-Tamayo J, Ferrari MC, Vaznaisiene D, Yusuf E, Aboltins C, Trebse R, Salles MJ, Benito N, Vila A, Toro MDD, Kramer TS, Petersdorf S, Diaz-Brito V, Tufan ZK, Sanchez M, Arvieux C, Soriano A; ESCMID Study Group for Implant-Associated Infections (ESGIAI).

J Infect. 2019 Sep;79(3):199-205. doi: 10.1016/j.jinf.2019.07.003.

Origine e caratteristiche delle infezioni periprotesiche articolari ematogene

Origin and characteristics of haematogenous periprosthetic joint infection.

Rakow A, Perka C, Trampuz A, Renz N.

Clin Microbiol Infect. 2019 Jul;25(7):845-850. doi: 10.1016/j.cmi.2018.10.010.

In acute haematogenous periprosthetic joint infections (PJI) manifesting after a pain-free period, the haematogenous infection route should be considered and the primary infectious focus should be actively searched for. The cardiovascular system, skin and soft tissue, oral cavity, urogenital and gastrointestinal tracts were common origins of haematogenous PJI.

Infezioni periprotesiche da S. aureus vs. S. epidermidis – Esiti del trattamento di eradicazione di stipiti meticillino-resistenti e sensibili

Staphylococcus aureus versus Staphylococcus epidermidis in periprosthetic joint infection-Outcome analysis of methicillin-resistant versus methicillin-susceptible strains.

Hischebeth GT, Randau TM, Ploeger MM, Friedrich MJ, Kaup E, Jacobs C, Molitor E, Hoerauf A, Gravius S, Wimmer MD.

Diagn Microbiol Infect Dis. 2019 Feb;93(2):125-130.

Colonizzazione inguinale da Cutibacterium avidum negli obesi: potenziale fattore di rischio per infezioni periprotesiche dell’anca

Association of Cutibacterium avidum Colonization in the Groin With Obesity: A Potential Risk Factor for Hip Periprosthetic Joint Infection
Laura Böni; Stefan P Kuster; Bianka Bartik; Reinhard Zbinden; Patrick O Zingg …
Clinical Infectious Diseases, Volume 67, Issue 12, 28 November 2018, Pages 1878–1882

We found that 21 of 65 patients (32.3%) undergoing hip arthroplasty were colonized with Cutibacterium avidum in the hip area, mainly at the groin, as a potential risk factor for hip periprosthetic joint infections.

Compresse di gentamicina o spugnette impregnate per il trattamento di infezioni acute periprotesiche: non funzionano

Use of gentamicin-impregnated beads or sponges in the treatment of early acute periprosthetic joint infection: a propensity score analysis
Marjan Wouthuyzen-Bakker; Claudia A M Löwik; Bas A S Knobben; Wierd P Zijlstra; Joris J W Ploegmakers …
Journal of Antimicrobial Chemotherapy, Volume 73, Issue 12, 1 December 2018, Pages 3454–3459

Even after propensity score matching, failure rates remained higher if local gentamicin-impregnated beads and/or sponges were administered in early acute periprosthetic joint infections. Based on these results, their use should be discouraged.

Indagine su fattori di rischio e più frequenti patogeni causa delle infezioni periprotesiche di anca e ginocchio

Evaluating the microbial pattern of periprosthetic joint infections of the hip and knee.

Rosteius T, Jansen O, Fehmer T, Baecker H, Citak M, Schildhauer TA, Geßmann J.

J Med Microbiol. 2018 Nov;67(11):1608-1613.

Periprosthetic joint infection (PJI) is a devastating complication that leads to enormous economic and health care complaints from affected patients. The aim of this study is to identify the causative pathogens responsible for PJI, evaluate temporal trends concerning the pathogen pattern and identify potential risk factors for PJI … Patients suffering PJI present a certain risk profile with many comorbidities, e.g. high age and obesity. The observed microbiological pattern demonstrates the rise of high-resistance pathogens. Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-resistant Staphylococcus aureus (MRSA), coagulase-negative Staphylococcus (CoNS), Streptococcus, and Enterococcus were the pathogens mainly responsible.

Antibatterici attivi contro i biofilm stafilococcici nelle infezioni periprotesiche: conferme e sorprese

Unexpected synergistic and antagonistic antibiotic activity against Staphylococcus biofilms
G F Dall; S-T J Tsang; P J Gwynne; S P MacKenzie; A H R W Simpson …
Journal of Antimicrobial Chemotherapy, Volume 73, Issue 7, 1 July 2018, Pages 1830–1840

This study found that gentamicin and daptomycin were the only effective single-agent antibiotics against established Staphylococcus biofilms. Interestingly the addition of a bacteriostatic antibiotic was found to antagonize the ability of gentamicin to eradicate Staphylococcus biofilms.

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