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Protect commensal gut bacteria to improve antimicrobial stewardship

Protect commensal gut bacteria to improve antimicrobial stewardship.Papanicolas LE, Warner M, Wesselingh SL, Rogers GB.Clin Microbiol Infect. 2020 Jul;26(7):814-815. doi: 10.1016/j.cmi.2020.03.021. Epub 2020 Mar 28.PMID: 32234452 

The profound threat posed by increasing resistance to critical last-line agents in common bacterial pathogens demands the re-examination of antimicrobial stewardship measures. Current strategies are based on reducing unnecessary antibiotic prescription and promoting approaches to antibiotic selection that best preserve the efficacy of critically important drugs (broad-spectrum and later-generation agents). However, our ability to achieve these goals is greatly diminished by a failure to consider the impact of antibiotics on commensal gut microbiology.

Mixed fungaemia: an 18-year report from a tertiary-care university hospital and a systematic review

Mixed fungaemia: an 18-year report from a tertiary-care university hospital and a systematic review.Gülmez D, Alp S, Gursoy G, Ayaz CM, Dogan O, Arikan-Akdagli S, Akova M.Clin Microbiol Infect. 2020 Jul;26(7):833-841. doi: 10.1016/j.cmi.2020.03.030. Epub 2020 Apr 1.PMID: 32246995 Review.

While fungaemia caused by two or more different species of yeasts (mixed fungaemia, MF) is infrequent, it might be underestimated. This study aimed to determine the incidence of MF, clinical characteristics of the patients, and antifungal susceptibility profiles of the isolates with a systematic review of the literature.

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